Notes

Slide Show

Outline

1	Global fitting
2	Global Model-Fitting
3	Global Model-Fitting
4	Global Model-Fitting
5	Global Model-Fitting
6	Incomplete Data Sets
7	Concentration-Response Curves
8	Concentration-Response Curves
9	Concentration-Response Curves
10	Concentration-Response Curves
11	Concentration-Response Curves
12	Concentration-Response Curves
13	Concentration-Response Curves
14	Comparing Models
15	F-Test (Extra Sum-Of-Squares Test)
16	F-Test (Extra Sum-Of-Squares Test)
17	F-Test (Extra Sum-Of-Squares Test)
18	F-Test (Extra Sum-Of-Squares Test)
19	F-Test: Standard Example
20	F-Test: Standard Example
21	F-Test: Standard Example
22	F-Test after Global Fitting
23	Comparing Curves
24	Comparing Curves
25	Comparing Curves
26	How to answer? Rephrase the question to compare models, with our without sharing.
27	Comparing Curves
28	Comparing Curves
29	Comparing Curves
30	Comparing Curves
31	Comparing Curves
32	Comparing Parameters
33	Comparing Parameters
34	Comparing Parameters
35	Comparing Parameters
36	Comparing Parameters
37	Comparing Parameters
38	Comparing Parameters
39	Comparing Parameters
40	Fitting Complex Models
41	Example 1: Radioligand Saturation Binding
42	Example 1: Radioligand Saturation Binding
43	Example 1: Radioligand Saturation Binding
44	Example 1: Radioligand Saturation Binding
45	Example 1: Radioligand Saturation Binding
46	Example 1: Radioligand Saturation Binding
47	Example 1: Radioligand Saturation Binding
48	Example 1: Radioligand Saturation Binding
49	Example 1: Radioligand Saturation Binding
50	Example 1: Radioligand Saturation Binding
51	Example 1: Radioligand Saturation Binding
52	Example 1: Radioligand Saturation Binding
53	Example 1: Radioligand Saturation Binding
54	Example 1: Radioligand Saturation Binding
55	Example 2: Homologous Competition Binding
56	Example 2: Homologous Competition Binding
57	Example 2: Homologous Competition Binding
58	Example 2: Homologous Competition Binding
59	Example 2: Homologous Competition Binding
60	Example 2: Homologous Competition Binding
61	Example 2: Homologous Competition Binding
62	In Prism 4
63	Example 2: Homologous Competition Binding
64	Example 2: Homologous Competition Binding
65	Example 2: Homologous Competition Binding
66	Example 2: Homologous Competition Binding
67	Example 2: Homologous Competition Binding
68	Example 3: Agonist-Antagonist C/R Curve Analysis
69	Example 3: Agonist-Antagonist C/R Curve Analysis
70	Example 3: Agonist-Antagonist C/R Curve Analysis
71	Example 3: Agonist-Antagonist C/R Curve Analysis
72	Example 3: Agonist-Antagonist C/R Curve Analysis
73	Example 3: Agonist-Antagonist C/R Curve Analysis
74	Example 3: Agonist-Antagonist C/R Curve Analysis
75	How to set constants with different values for each data set in Prism 4
76	Example 3: Agonist-Antagonist C/R Curve Analysis
77	Example 3: Agonist-Antagonist C/R Curve Analysis
78	Example 3: Agonist-Antagonist C/R Curve Analysis
79	Example 3: Agonist-Antagonist C/R Curve Analysis
80	Other Examples
81	Other Examples – Antagonist Inhibition Curves
82	Other Examples – Kinetic Binding Curves
83	Other Examples – Receptor Inactivation Curves
84	Other Examples – Receptor Inactivation Curves
85	"Dr Arthur Christopoulos Dept." Dr Arthur Christopoulos Dept. of Pharmacology University of Melbourne arthurc1@unimelb.edu.au