GraphPad Curve Fitting Guide

Sum-of-squares

Sum-of-squares

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Sum-of-squares

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Nonlinear regression finds the curve that minimizes the sum of square of the distances of the points from the curve. So Prism reports that sum-of-square value. This is useful if you want to compare Prism with another program, or compare two fits manually. Otherwise, the value is not very helpful.

If you choose to differentially weight your data, Prism reports both the absolute and the weighted sum-of-squares.