GraphPad Prism 8 User Guide

Difference between Windows and Mac

Difference between Windows and Mac

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Difference between Windows and Mac

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Prism Windows works as you expect. You work on a temporary copy of the program in transient computer memory (RAM) until you save.

Prism Mac works differently. You don't ever need to use the Save command, as all changes are saved automatically. Read this overview, these details, and this explanation about what happened to the File Save command.