Prism is still Prism
Prism works as it always did. If you know Prism 6 or 7, you can discover most of the new features as you use Prism. It won't be hard to adjust. But there are three things you should know before you start.
Switch between analysis pages using analysis tabs
Many analyses in Prism present results on multiple pages (sometimes called subpages or views). With earlier versions of Prism, you would navigate between them using subpages indented under the analysis name in the navigator. The Prism 8 navigator does not show subpages. Instead, they are shown as analysis tabs above the results. The results on some tabs are designed for graphing, not viewing. These are hidden by default but can be shown using the drop down menu.
New family pane at the bottom of the navigator
The navigator in Prism 8 always shows a panel showing the family of sheets related to the current sheet, making it easier to move among related sheets. This replaces the old Family folder, which few people used. Chains of analyses are automatically indented, replacing the old Data+Results folder.
Windows only: No more child windows in parent windows
With prior versions of Prism for Windows, there was one master (parent) window that could contain multiple child windows each with its own project file. With a trick, you could create two separate parent windows.
With Prism 8 Windows, the concept of parent or master window is gone. Each open file has its own window. This is the modern way of working (which almost all applications use) and makes it much easier to work with multiple displays. But it is a change, and may take a while to get used to.
Prism Mac always showed each open file in its own window, so there is no change with Prism 8.