GraphPad Curve Fitting Guide

log of exponential growth

log of exponential growth

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log of exponential growth

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Introduction

With exponential growth, the population keeps growing forever with a constant doubling time. If you plot the logarithm of population as Y (instead of the population itself), the graph is linear.  When you fit an exponential model, you want the scatter to be about the same at all time points. This assumption is often more likely to be true of you fit the log of concentration rather than concentration.

Step by step

Create an XY table. Enter time values into X and the logarithm of population values into Y.  The natural logarithm is use most often for these kinds of data.

After entering data, click Analyze, choose nonlinear regression, choose the panel of growth equations, and choose Log of exponential growth.

Consider whether logY0 should be constrained to a fixed values.

Model

Y=logY0 + k*X

 

Interpret the parameters

logY0 is the starting population in the same logarithmic units as Y

k is the rate constant (inverse of the X time units).

DoublingTime is the time needed for the population to double. It is calculated as ln(2)/k.

Relationship between this equation and exponential (Malthusian) growth

If the data were transformed using the natural logarithm, then k in this fit is equivalent to k in the exponential (Malthusian) growth equation and the logY0 here is equivalent to the logarithm of Y0 in the exponential equation.

But the two values of k won't usually be identical. The Exponential growth equation is more appropriate when the scatter of data around the curve is the same at all time points. The log of exponential growth equation is more appropriate when the scatter of data around the line is the same at all time points.