Can I configure Prism so that it opens the way it was closed?

Yes, if you use Prism for Windows version 3 or 4. To exit, hold the CTRL key while choosing Exit from the File menu. When you start Prism again, your projects will open just as you left them. If you work on several projects at once, this is a convenient method to interrupt and restart your work.

Please note. When you exit Prism in this way, your work is stored in PZB files in the temporary folder. Don't accidentally delete these files.