KNOWLEDGEBASE - ARTICLE #1450

Hill in Hell, and more. Recommended book: Drug-Acceptor Interactions

Last modified March 23, 2009

Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects

Freely available online

While overkill for most pharmacologists, it is a unique resource for people who need to deal with complex dose-response relationships, including allosteric interactions, synergy, multi-step binding, cubic binding models and much more. It deals only with systems at equilibrium, so does not cover kinetics.

If you are curious, start with his chapter Hill in Hell, which explains many variations on the Hill equation, and the many uses of the term "logistic". If you haven't heard of the Hill equation, this book is not for you!. 

 

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