Prism 11.0.0

Prism 11.0.0 was released on February 17, 2026.

Introducing Prism Pro

Prism 11 delivers our most powerful and advanced updates yet for working with multiple variables data, all available with our new Prism Pro and Prism Enterprise plans. Check out the complete set of the new and improved features available in Prism 11 below.

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Calculated Variables from In-table Formulas

Create new variables with spreadsheet-style formulas directly inside Multiple Variables tables, included with Prism Pro and Enterprise.

Familiar Spreadsheet Experience: Just like Excel or Google Sheets, select an empty variable, and type "=" to start a formula. Perform simple operations such as unit conversion and ratios, or build more complex calculations by chaining functions and operators. Unlike spreadsheet formulas that work cell-by-cell, Prism formulas operate on entire variables at once, generating dynamic results on each row of the variable.

Real-Time Updates: Edit a variable formula at any time. Calculated values update automatically when source values change. Created variables can be used as independent, dependent, or grouped variables in any analysis that works with Multiple Variables tables.

Cleaner Project Files: Created variables become part of the data table itself rather than separate transform or analysis sheets. This lets you generate transformed variables specifically for analyses or graphs, keeping your project files cleaner and your workflow more efficient.

3 quick ways to access: Start by typing = in any cell, from the toolbar, or via Insert → Calculated Variable.

Why Calculated Variables from In-Table Formulas Matter

This is one of Prism's most requested capabilities. Previously, simple calculations like ratios or log transforms required creating separate analysis sheets, cluttering your Navigator and making it hard to track your workflow. Now you can do these transformations directly in your data table with formulas that update automatically - just like Excel or Google Sheets. This saves significant time in everyday data prep and keeps your projects organized.

Available to all users with a subscription during the beta testing period

Multifactor ANOVA

One analysis for designs with any number of factors, available in Prism Pro and Enterprise.

Analyze experiments with multiple factors using a single, unified approach - no matter how many factors you have.

Ultimate Flexibility: Handle one-way through N-way designs with the same interface and workflow

Drag-and-Drop: Assign response and grouping variables from Multiple Variables tables with ease

No Data Reorganization: Add or remove factors without restructuring your data - each row is an observation, each column is a variable

Complete Post-Hoc Suite: Perform comparisons of main effects, simple effects, or cell-by-cell patterns with your choice of correction methods

A Modern Approach to Factorial Experiments

Traditional ANOVA in Prism required different data table formats for different numbers of factors - adding a third factor meant completely restructuring your data. Multifactor ANOVA eliminates this limitation. Use one Multiple Variables table for all factorial designs, and add or remove factors simply by reassigning variables. No more rebuilding tables when your experimental design evolves. Whether you're investigating how drug, genotype, and time combine to affect gene expression, or exploring how multiple environmental factors influence organism behavior, multifactor ANOVA provides the statistical muscle you need with the flexibility modern research demands.

Available to all users with a subscription during the beta testing period

Classic Analyses from Multiple Variables Data Tables

A new unified approach for greater flexibility in how you organize and analyze your data, included with Prism Pro and Enterprise plans.

Perform t-tests, nonlinear regression, and Kaplan-Meier survival analysis directly from Multiple Variables tables by assigning variables to analysis roles.

• One Table, Multiple Analyses: Organize your data in one consistent structure and run t-tests, nonlinear regression, and survival analysis. With more analyses coming in future releases
• Intuitive Variable Assignment: Specify which columns serve as response variables, which define experimental groups, and (for paired analyses) which identify matched subjects
• Seamless Switching: Update analysis designs by reassigning variables instead of reorganizing data
• Multi-Factor Support: For nonlinear regression and survival, assign multiple categorical variables and Prism creates individual results for each combination

Why it matters 

Previously, performing t-tests required Column tables, nonlinear regression needed XY tables, and survival analysis needed Survival tables. Depending on your experiment, you'd need to create separate tables for each analysis and ensure data was structured correctly for each test. Now organize your data once in a Multiple Variables table and run any of these analyses by simply assigning variables—no reformatting needed. This release includes three essential analyses, with more being added in future releases as we expand this framework. Of course, you can still work directly with Column, XY, or Survival tables if you prefer—this simply gives you more flexibility in how you structure your data.

Real-World Examples:

• Biomarker t-test: Want to run a t-test on a specific biomarker across two experimental groups? Simply specify the response variable and the grouping variable. Change to a different biomarker? Just reassign the response variable
• Dose-response curves: Need to fit dose-response curves for multiple cell lines under various conditions? Specify your predictor variable, response variables, and grouping factors, and Prism creates individual regression analyses for each combination
• Multi-factor experiments: The variable assignment interface makes it straightforward to specify which columns serve as response variables, which define experimental groups, and (for paired analyses) which identify matched subjects

Available to all users with a subscription during the beta testing period

Comprehensive Effect Size Reporting

Report the magnitude of effects, not just statistical significance, included with Prism Pro and Enterprise plans.

Prism 11 expands effect size reporting across multiple analyses to support modern statistical interpretation and publication standards.

• Beyond P Values: Report effect sizes to understand not just whether an effect exists, but how large and meaningful it is
• Confidence Intervals: Understand not just the size (estimate) of an effect, but how precisely it's been estimated
• Standardized Effect Sizes: Compare effect magnitudes across studies and designs with numerous common metrics

Included Metrics

• ANOVAs: eta-squared, partial eta-squared, Cohen's f (available for one-way, two-way, three-way, repeated measures (GLM), and multifactor ANOVA)
• Contingency tables: Phi coefficient for 2×2 tables and Cramér's V for larger tables, with confidence intervals calculated for both effect sizes
• t-tests: Cohen's d and Hedges' g for all t-test types, plus Glass's Δ for unpaired t-tests (parametric tests only)

Why it matters

Prism now automatically calculates and reports effect sizes you previously had to compute manually or look up in other software. This update brings Prism in line with modern publication standards—many journals now require effect size reporting alongside p-values. Having these metrics built directly into your results saves time and ensures you're meeting current best practices without extra steps.

Browser File Upload to Prism Cloud

Upload Prism files directly through the web interface - no Prism desktop app required. Available with any Prism subscription that includes Prism Cloud Workspace.

Work From Anywhere: Upload .prism files directly through your browser with drag-and-drop or browse to select

Seamless Integration: Works with existing workspace structure for quick sharing and collaboration

Why it matters

Previously, uploading to Prism Cloud required the desktop application. Now you can upload directly from any browser - perfect for remote work, computers without Prism installed, or quick file sharing. Get your data, results, and graphs into the cloud faster and share them with collaborators who need access without ever opening the desktop app.

Content Manager Role in Prism Cloud

Purpose-built for team organization and workspace management, included in Prism Organization and Enterprise plans.

A new workspace role designed for the team member who keeps everything organized—perfect for lab managers, project coordinators, or team leads.

Full Content Control, Not Full Admin: Move, delete, restore, and organize any project or folder in common areas without accessing sensitive workspace settings or billing Smart Permissions: Automatically has editor access in common folders; follows assigned permissions in private folders Keep Teams Productive: Let scientists focus on research while Content Managers maintain clean, organized workspaces

Why it matters

Previously, you had only two options: give someone full Admin access or limit them to basic Creator or commenter permissions. Content Manager fills this gap—it's designed for lab managers and coordinators who need to organize and manage projects across teams without accessing sensitive administrative functions. This role has been specifically requested by enterprise customers managing large, collaborative workspaces.

When to Use Content Manager:

• Your lab manager needs to organize projects across multiple teams
• Your team has grown and needs someone to keep the workspace tidy without full admin privileges

Complete Release Notes

New Features

Multifactor ANOVA

Implemented multifactor ANOVA for complex experimental designs with multiple factors.

Classic Analyses from MV Data Tables

Implemented variable assignment options in analysis dialogs to enable the following classic analyses from Multiple Variables data tables

• Enabled performing nonlinear regression analysis from MV data tables
• Enabled performing survival analysis from MV data tables
• Enabled performing t-test analysis from MV data tables

Calculated Variables

Added the ability to perform data transformations directly within data tables.

Feature Improvements

Pro and Enterprise License Improvements

Effect Sizes

Added effect size calculations for:

• ANOVAs
• Contingency table analyses
• t-tests

Multiple Linear Regression

For models including interactions between categorical variables, Prism now reports a complete ANOVA table in the results (previously only a basic version was provided).

Available Across All License Types

Nonlinear Regression

• Added the new transform "Inflection Point = (1/k)*ln((YM-Y0)/Y0)" for the logistic growth function
• Enabled the "Don't fit points when..." option on the Range tab of nonlinear regression when X is defined as a series

Data Table Management

• Implemented Freeze and Unfreeze Data Tables commands
• Added the command to unlink local files from Prism Cloud

Sample Data Files

• Added eight new tutorial data files covering new and existing functionality for the multiple variables data table

Performance Improvements

• Prism now avoids unnecessary recalculations when making changes to variables in multiple variables data tables that are not used as inputs for the analysis
• Improved the performance of calculating "Correlation" and "Interpolate a standard curve" analyses when performed on large data sets
• Improved performance of switching between sheets in a Prism project after performing "Correlation", "Select and Transform", "Extract and rearrange", "Simple linear regression", or "Plot a function" analyses on large data sets
• Improved the performance of Prism when closing projects without saving after recalculating a "Correlation", "Select and transform", "Extract and rearrange", "Simple linear regression", or "Plot a function" analysis performed on large data sets
• (Mac) Improved the performance of Prism when closing projects without saving after recalculating a majority of analyses
• (Mac) Improved the performance of switching between data tables and results sheets containing large data sets in Dark Mode

Analysis-Related Bug Fixes

• Fixed an issue in two-way ANOVA where the narrative results incorrectly indicated no interaction in the model
• Fixed an issue where the correlation result sheet displayed empty cells instead of 'r=1' when the data table contained columns with identical values
• Fixed an issue where data in the Elbow plot, Silhouette plot, and Gap plot results of hierarchical clustering analysis were not updated after amending options in the analysis parameters dialog
• (Windows) Fixed an issue where 'CI of diff' values were absent in the Multiple comparisons results of two-way ANOVA with Dunnett's test if the source data table contained missing values

Graphing Bug Fixes

• Fixed an issue where the line at the grand mean/median was not displayed on the Grouped Superimposed Scatter graph when the first dataset contained missing or excluded values
• Fixed an issue where part of the spike on the XY graph was unexpectedly shown on the axis segment, even though the range of the segment was outside the values for this spike
• Fixed an issue where symbol labels were not removed from the PC Scores graph generated by Principal Component Analysis if the dependent variable was excluded or deleted from the data table
• Fixed an issue where the color of additional grid lines was not applied to the bubble plot after performing the Magic command
• Fixed an issue where the minimum and maximum axis range values of the Loadings graph from Principal Component Analysis were not updated after changing analysis parameters
• Fixed an issue where updating a multiple variables graph resulted in a missing legend on the graph, and incorrect color assignments when categorical levels were deleted and then restored with the Undo command
• (Windows) Fixed an issue where formatting applied to a single bar in the nested graph was incorrectly affecting the entire dataset
• (Windows) Fixed an issue where exporting multiple layout figures from Prism to MS PowerPoint using the "SendToPP" script caused figures to appear smaller
• (Windows) Fixed an issue where graph titles were not automatically updated to reflect new column titles in the analyzed data table when duplicating data families and creating graphs for each dataset
• (Windows) Fixed an issue where survival graphs appeared corrupted in reopened PZFX/PZF projects saved without visiting results and graph sheets
• (Windows) Fixed an issue where Floating bars and Box & Whiskers appeared corrupted on nested graphs if a custom range was applied to the segmented Y-axis
• (Windows) fixed an issue in which text objects with special symbols added to XY graphs containing large amounts of data unexpectedly appeared bold after placing the graph on a layout sheet
• (Windows) Fixed an issue in which symbols on a multiple variables graph had the wrong colors and the order in the legend unexpectedly changed in .pzfx/.pzf files if one of the levels in the data table had previously been replaced
• (Windows) Fixed an issue in which using the Magic tool on multiple variables graphs with mixed defaults and custom axis titles caused inconsistent axis title updates
• (Windows) Fixed the issue in which the curve for another data set was plotted on a graph that was created using the "Create a new graph for each data set option" if the data table contained empty columns
• (Mac) Fixed an issue where the position of row/column labels was not applied to the target heatmap graph after performing the Magic operation when the position of row/column labels on the example graph was set to 'Left' or 'On Top'
• (Mac) Fixed an issue where text added to the layout sheet appeared blurry and rasterized when exported to EPS format due to an unexpected default opacity level of 85%

Other Bug Fixes

• Fixed an issue where the 'Apply formatting applied to individual points or bars' option was unexpectedly dimmed in the Magic Step 2 dialog for Grouped Interleaved scatter with bars graphs when no changes were made to symbols
• Fixed an issue where changing the axis color in the Format Axes dialog did not update the color of additional grid lines in the Format Additional Ticks and Grids dialog
• Fixed a crash when invoking the Hook Constant dialog with two-way ANOVA results if a number was set as the row factor name in the parameters dialog
• Fixed an inconsistency where 'Title' was used instead of 'Name' in various locations, including data tables, the Format Data Table dialog, and the Select and Transform dialog, ensuring accurate terminology throughout the GraphPad Prism user interface
• Fixed an issue where orphaned Select and Transform result sheets appeared as frozen with incorrect floating notes when opening projects created in Prism 10.5.0 or earlier versions
• Fixed an issue where a 'Disk or memory error occurred' alert appeared when assigning a new data table to an orphaned Select and Transform analysis that had a 'Variable vs. Value' filter option with a categorical variable assigned to it
• Fixed a crash when performing K-means clustering analysis when the source data table contained only one value in any dataset and the minimum and maximum number of clusters were both set to 1
• Updated the visual representation of the Gompertz growth equation
• Fixed the issue in which custom floating note size was not preserved after saving and re-opening a project
• (Windows) Fixed the issue in which Prism would crash while assigning a new data set to a Parts of Whole graph in the "Format Graph" dialog
• (Windows) Fixed the issue in which it was impossible to update a previously closed and re-opened project in Prism Cloud due to an unexpected alert that appeared after publishing and closing a second project
• (Windows) fixed the issue in which the text of the "Narrative results" tab for two-way ANOVA appeared corrupted while scrolling the page in a resized Prism window
• (Mac) Fixed an uncommon issue in which Prism would hang for several seconds after re-saving a modified project or saving a second project with the same name
• (Mac) Fixed the issue in which it was impossible to generate X values as a series using the "Format Data Table" dialog if the project contained at least one non-empty data table

Windows-Specific Bug Fixes

• Fixed an issue where an incorrect image file format was selected when using the Browse dialog for export for graphs or layouts
• Fixed an issue where a blank extra row was created every time a row moved to the bottom in the Constant section of the Info sheet
• Fixed a crash when attempting to hook an analysis constant generated from the nonlinear regression results sheet in the reopened Parameters dialog invoked from the linked graph
• Fixed a crash when exporting violin graphs to SVG format when the border thickness of the violin was set to 'None'
• Fixed a crash that occurred when closing a project containing Principal Component Analysis results sheets if generated graphs were placed on the layout sheet and another data table was assigned to the analysis
• Fixed an issue where multiple variable graphs published in Prism Cloud were displayed at 7% scale
• Fixed an issue where .PRISM files that contained Latin, Cyrillic, Japanese, Chinese, or special symbols were not found when using the system search through file content
• Fixed an issue where multi-line variable names were truncated in the dropdowns of Create New Graph, Change Graph Type, Parameters: Hierarchical Clustering, and Parameters: Extract and Rearrange dialogs
• Fixed an issue where the 'Clusters appearance' dropdowns in the Dendrogram section of the Inspector's Data tab had different lengths for Horizontal and Vertical Axis subtabs if the 'None' option was selected
• Fixed an issue that prevented scrolling back to the sheet with multiple variables graph after drawing a line beyond the canvas
• Fixed an issue where projects from LabArchives could not be updated without saving them locally due to an unexpected 'Not enough space to save data on disk' alert
• Fixed an issue where the Graph Inspector incorrectly scaled when changing the DPI of the display
• Fixed an issue in which performing Undo actions after switching data table types and then reformatting Y values caused Y columns to appear empty in the reopened project
• Fixed an issue in which Prism became deactivated after launching multiple instances by opening two or more project files simultaneously from Windows Explorer, resulting in required reactivation on the next app launch
• Fixed the issue in which it was possible to apply negative values in the "Death/Event" and "Censored Subject" fields on the Model tab of the Parameters: Simple Survival Analysis (Kaplan-Meier) dialog
• Fixed the issue in which the name of the results sheet created by the "Wand" tool was not updated after renaming the linked data table
• Improved the file auto-recovery features so that Prism is now able to open legacy PZF files with corrupted graph axes structures

Mac-Specific Bug Fixes

• Fixed an issue where deleting a results sheet in analyses that generate graph sheets (e.g., t-test, transform, two-way ANOVA) inadvertently removed unlinked graphs
• Fixed an issue where the data table was unexpectedly displayed in the Print dialog instead of the graph sheet when printing immediately after reopening a file
• Fixed a crash when applying the Magic tool to dendrogram graphs with custom branch appearance
• Fixed text truncation in the Repeated Measures tab of the two-way ANOVA parameters dialog, ensuring that all options are fully visible when users open the dialog
• Fixed an issue where an inappropriate contextual menu with commands related to toolbar appearance was shown for the Prism window header
• Fixed an issue where data from a text file pasted as a link on a data table was not updated automatically, even though the corresponding option was enabled in the Import and Paste Special Choices dialog
• Fixed an issue where the InsertData <row>,<col>,<subcol> command did not correctly place data in the specified column title cell when using the ForEachSheet loop in projects with four or more data tables
• Fixed an issue where section titles for horizontal and vertical axis options were mixed up in the Dendrogram tab of the Format Graph dialog
• Fixed a visual issue in which dropdown menus appeared corrupted in the Residuals tab of the Cox regression parameters dialog on macOS 26
• Fixed a crash that occurred when exporting a blank layout to PDF, EPS, or SVG with the “Enlarge/shrink to match width” option selected in the Export dialog
• Fixed an issue in which Prism would crash upon opening the color scheme dropdown menu for changing the color of the branches of a dendrogram if a single color was applied via the Format Graph dialog
• Fixed an issue in which Prism would crash upon switching to the Heatmap tab of the Hierarchical clustering results sheet after some data was excluded from the analyzed data table
• Fixed the issue in which it was impossible to unlink a hooked constant value from a multiple variables graph
• Improved compatibility of Prism with Keynote (version 15) when sending a graph and layout sheets using the "Send to Keynote" command
• Fixed an issue where performing Undo → Redo → Undo actions after deleting a source data table could break the project, leaving new result sheets blank and incorrectly named

Plan Definitions

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