Comprehensive Analysis and Powerful Statistics, Simplified
Organize Your Data Effectively
Prism is specifically formatted for the analyses you want to run, including analysis of quantitative and categorical data. This makes it easier to enter data correctly, choose suitable analyses, and create stunning graphs.Start a Free Trial
Perform The Right Analysis
Avoid statistical jargon. In clear language, Prism presents an extensive library of analyses from common to highly specific— t tests, one-, two- and three-way ANOVA, linear and nonlinear regression, dose-response curves, binary logistic regression, survival analysis, principal component analysis, and much more. Each analysis has a checklist to help you understand the required statistical assumptions and confirm you have selected an appropriate test.Start a Free Trial
Get Actionable Help As You Go
Reduce the complexity of statistics. Prism’s online help goes beyond your expectations. At almost every step, access thousands of pages from the Prism User Guides. Learn from video lessons, guides and educational materials through Prism Academy. Browse the Graph Portfolio and learn how to make a wide range of graph types. Tutorial data sets also help you understand why you should perform certain analyses and how to interpret your results.Start a Free Trial
Work Smarter, Not Harder
One-Click Regression Analysis
No other program simplifies curve fitting like Prism. Select an equation and Prism does the rest—fits the curve, displays a table of results and function parameters, draws the curve on the graph, and interpolates unknown values.Start a Free Trial
Focus on Your Research, Not Your Software
Prism handles the coding for you. Graphs and results are automatically updated in real time. Any changes to the data and analyses— direct entry of data, omitting erroneous data, correcting typos, or changing analysis choices—are reflected in results, graphs, and layouts instantaneously.Start a Free Trial
Automate Your Work Without Programming
Automatically add multiple pairwise comparisons to your analysis with a single click. For customization options of these lines and asterisks, simply click the toolbar button again. Make adjustments to the data or the analysis, and the results displayed on the graph will update automatically.Start a Free Trial
The Fastest Way to Elegantly Graph and Share Your Work
Countless Ways to Customize Your Graphs
Focus on the story in your data, not manipulating your software. Prism makes it easy to create the graphs you want. Choose the type of graph, and customize any part—how the data is arranged, the style of your data points, labels, fonts, colors, and much more. The customization options are endless.Start a Free Trial
Export Publication-Quality Graphs With One Click
Reduce time to publish. Prism allows you to customize your exports (file type, resolution, transparency, dimensions, color space RGB/CMYK) to meet the requirements of journals. Set your defaults to save time.Start a Free Trial
Share more than your graphs. Prism’s comprehensive record of your data enables effective collaboration with other scientists. All parts of your Prism project (raw data, analyses, results, graphs, and layouts) are contained in a single file that you can share with one click. Now others can easily follow your work at every step, enhancing the clarity of your findings and streamlining your collaborative efforts.Start a Free Trial
Discover What’s New in Prism!
Introducing an even more powerful Prism featuring enhanced data visualization and graph customization, more intuitive navigation, and more sophisticated statistical analyses.
Enhanced Data Visualization and Graphs Customization
Create Bubble Plots directly from raw data, encoding variables for position (X- and Y-coordinates), color, and size
Visualize distributions of large data sets with either extended or truncated violin plots
Automatically display your analysis results
Major improvements in showing general data trends through Akima splines and smoothing splines with improved control over the number of knots, or inflection points
Improved Graphing and Customization Options
Stars on Graph
Automatically add multiple comparison results to graphs
Automatically label bar graphs
Annotate your bar graphs with values for the means, medians, or sample sizes to emphasize what's important in your work
Improved grouped graphs
Easily create graphs that show both individual points (scatter) along with bars for mean (or median) and error bars
More Intuitive Navigation
Find related sheets easily
New family panel shows the family of sheets related to the current sheet, and chains of analyses are automatically indented
Easily navigate between multiple results tables
Analyses with multiple results tables now grouped into a single sheet with tabs for each result table; choose which tabs to show or hide
Search by sheets with highlights or notes of specified color
Now Featuring Eight Kinds of Data Tables
Multiple variables data table
Each row represents a different subject and each column is a different variable, allowing you to perform multiple linear regression (including Poisson regression), extract subsets of data into other table types, or select and transform subsets of the data. Prism’s multiple variable tables support text variables and have the ability to define variable types
Nested data table
Analyze and visualize data that contains subsets within related groups; Perform nested t tests and nested one-way ANOVA using data within these tables
More Sophisticated Statistical Analyses
Perform repeated measures ANOVA – even with missing data
Now Prism will automatically fit a mixed effects model to complete this analysis
Perform simple and multiple logistic regression
Fit a model to a binary outcome (yes/no, win/lose, pass/fail) based on one predictor variable (simple logistic regression) or many predictor variables (multiple logistic regression)
Principal Component Analysis
Calculate and select the principal components that describe the greatest amount of variance in your data. Choose from selection techniques including Parallel Analysis via Monte Carlo simulation, Eigenvalue threshold, Proportion of Variance threshold, and more
Multiple t test (and nonparametric) analyses
Perform multiple independent two-sample comparison tests simultaneously. Select from parametric/nonparametric tests, and specify if data are unpaired/paired
Analyze categorical variables with text in Multiple Linear and Multiple Logistic Regression
No coding required! Prism will automatically encode categorical variables and perform the analysis. Specify a reference and organize all levels of categorical variables in a model for clear, readable results
Interpolation from multiple linear and multiple logistic regression
Use the specified model to predict values for the dependent variable based on data in the data table or using theoretical values specified in the analysis
No credit card required.
Discover the Breadth of Statistical Features Available in Prism
- Paired or unpaired t tests. Reports P values and confidence intervals.
- Automatically generate volcano plot (difference vs. P value) from multiple t test analysis.
- Nonparametric Mann-Whitney test, including confidence interval of difference of medians.
- Kolmogorov-Smirnov test to compare two groups.
- Wilcoxon test with confidence interval of median.
- Perform many t tests at once, using False Discovery Rate (or Bonferroni multiple comparisons) to choose which comparisons are discoveries to study further.
- Ordinary or repeated measures ANOVA followed by the Tukey, Newman-Keuls, Dunnett, Bonferroni or Holm-Sidak multiple comparison tests, the post-test for trend, or Fisher’s Least Significant tests.
- One-way ANOVA without assuming populations with equal standard deviations using Brown-Forsythe and Welch ANOVA, followed by appropriate comparisons tests (Games-Howell, Tamhane T2, Dunnett T3)
- Many multiple comparisons test are accompanied by confidence intervals and multiplicity adjusted P values.
- Greenhouse-Geisser correction so repeated measures one-, two-, and three-way ANOVA do not have to assume sphericity. When this is chosen, multiple comparison tests also do not assume sphericity.
- Kruskal-Wallis or Friedman nonparametric one-way ANOVA with Dunn's post test.
- Fisher's exact test or the chi-square test. Calculate the relative risk and odds ratio with confidence intervals.
- Two-way ANOVA, even with missing values with some post tests.
- Two-way ANOVA, with repeated measures in one or both factors. Tukey, Newman-Keuls, Dunnett, Bonferroni, Holm-Sidak, or Fisher’s LSD multiple comparisons testing main and simple effects.
- Three-way ANOVA (limited to two levels in two of the factors, and any number of levels in the third).
- Analysis of repeated measures data (one-, two-, and three-way) using a mixed effects model (similar to repeated measures ANOVA, but capable of handling missing data).
- Comparison of data from nested data tables using nested t test or nested one-way ANOVA (using mixed effects model).
- Fit one of our 105 built-in equations, or enter your own. Now including family of growth equations: exponential growth, exponential plateau, Gompertz, logistic, and beta (growth and then decay).
- Enter differential or implicit equations.
- Enter different equations for different data sets.
- Global nonlinear regression – share parameters between data sets.
- Robust nonlinear regression.
- Automatic outlier identification or elimination.
- Compare models using extra sum-of-squares F test or AICc.
- Compare parameters between data sets.
- Apply constraints.
- Differentially weight points by several methods and assess how well your weighting method worked.
- Accept automatic initial estimated values or enter your own.
- Automatically graph curve over specified range of X values.
- Quantify precision of fits with SE or CI of parameters. Confidence intervals can be symmetrical (as is traditional) or asymmetrical (which is more accurate).
- Quantify symmetry of imprecision with Hougaard’s skewness.
- Plot confidence or prediction bands.
- Test normality of residuals.
- Runs or replicates test of adequacy of model.
- Report the covariance matrix or set of dependencies.
- Easily interpolate points from the best fit curve.
- Fit straight lines to two data sets and determine the intersection point and both slopes.
- Kaplan-Meier survival analysis. Perform nonparametric survival analysis for different groups, and compare the estimated survival curves for each group with the log-rank test (including test for trend).
- Cox proportional hazards regression. Perform semi-parametric survival analysis that allows for the inclusion of additional continuous or categorical predictor variables (covariates). Automatically generate graphs of estimated survival curves for any set of predictor variable values.
Principal Component Analysis (PCA)
- Component selection via Parallel Analysis (Monte Carlo simulation), Kaiser criterion (Eigenvalue threshold), Proportion of Variance threshold, and more.
- Automatically generated Scree Plots, Loading Plots, Biplots, and more.
- Use results in downstream applications like Principal Component Regression.
Multiple Variable Graphing
- Specify variables defining axis coordinates, color, and size.
- Create Bubble Plots.
- Calculate descriptive statistics: min, max, quartiles, mean, SD, SEM, CI, CV, skewness, kurtosis.
- Mean or geometric mean with confidence intervals.
- Frequency distributions (bin to histogram), including cumulative histograms.
- Normality testing by four methods (new: Anderson-Darling).
- Lognormality test and likelihood of sampling from normal (Gaussian) vs. lognormal distribution.
- Create QQ Plot as part of normality testing.
- One sample t test or Wilcoxon test to compare the column mean (or median) with a theoretical value.
- Identify outliers using Grubbs or ROUT method.
- Analyze a stack of P values, using Bonferroni multiple comparisons or the FDR approach to identify "significant" findings or discoveries.
Simple Linear Regression and Correlation
- Calculate slope and intercept with confidence intervals.
- Force the regression line through a specified point.
- Fit to replicate Y values or mean Y.
- Test for departure from linearity with a runs test.
- Calculate and graph residuals in four different ways (including QQ plot).
- Compare slopes and intercepts of two or more regression lines.
- Interpolate new points along the standard curve.
- Pearson or Spearman (nonparametric) correlation.
Generalized Linear Models (GLMs)
- Generate models relating multiple independent variables to a single dependent variable using the new multiple variables data table.
- Multiple linear regression (when Y is continuous).
- Poisson regression (when Y is counts; 0, 1, 2, …).
- Logistic regression (when Y is binary; yes/no, pass/fail, etc.).
Clinical (Diagnostic) Lab Statistics
- Bland-Altman plots.
- Receiver operator characteristic (ROC) curves.
- Deming regression (type ll linear regression).
- Simulate XY, Column or Contingency tables.
- Repeat analyses of simulated data as a Monte-Carlo analysis.
- Plot functions from equations you select or enter and parameter values you choose.
- Area under the curve, with confidence interval.
- Transform data.
- Identify outliers.
- Normality tests.
- Transpose tables.
- Subtract baseline (and combine columns).
- Compute each value as a fraction of its row, column or grand total.
Prism is available on Mac and Windows.