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Relative vs absolute IC50; Fitting the absolute IC50; Incomplete dose-respone curves; Troubleshooting fits of dose-response curves. Dose-response - Stimulation ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

Instead you enter the concentration of radioligand and its Kd as constants, and Prism directly fits the Ki of your cold compound. If you want to know the IC50, ...

https://www.graphpad.com/guides/prism/7/curve-fitting/

Relative vs absolute IC50; Fitting the absolute IC50; Incomplete dose-respone curves; Troubleshooting fits of dose-response curves. Dose-response - Stimulation ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

(This midpoint is sometimes called the IC50 or ED50). First let's look at the variables without a log transform, H+ and EC50. Both come pretty close to the ...

GraphPad FAQs

An alternative to the concept of "ambiguous" fits Starting with Prism 8.2, we offer a number of choices regarding how Prism should handle cases when the ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

Equation: Absolute IC50. Receptor binding - Key concepts; Receptor binding - Saturation binding; Receptor binding - Competitive binding; Receptor binding ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

Equation: Absolute IC50. Receptor binding - Key concepts; Receptor binding - Saturation binding; Receptor binding - Competitive binding; Receptor binding ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

If you are thinking about two drugs working on different sites on the same receptor, read up on allosteric interactions. This is a special case of drug synergy ...

GraphPad FAQs

Equation: Absolute IC50. Receptor binding - Key concepts; Receptor binding - Saturation binding; Receptor binding - Competitive binding; Receptor binding ...

https://www.graphpad.com/guides/prism/latest/curve-fitting/

Choose an equation where X is expected to be dose or concentration, and Prism will fit the EC50 or IC50 directly, with standard errors.

GraphPad FAQs